Phenotypes Associated with This Genotype

Genotype
MGI:4421410

• Allelic Composition: Snca^tm1Nbm/Snca^tm1Nbm; Tg(SNCA*A30P)1Nbm/Tg(SNCA*A30P)1Nbm; Tg(SNCA*A30P)2Nbm/Tg(SNCA*A30P)2Nbm
• Genetic Background: involves: 129S6/SvEvTac * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal intestinal transit time ( J:156741 )

♀ • whole-gut transit time (WGTT) is significantly prolonged compared to controls starting at 3 months through 12 months of age;

abnormal large intestinal transit time ( J:156741 )

♀ • motility of distal colon is reduced in males compared to controls at 6 and 12 months

♀ • amount of stool passed/unit time and stool water content are unchanged at 3 months of age but by 6 months these parameters are reduced to comparable degrees

♀ • at 12 months of age, changes in stool production and water content are even more marked

♀ • reduction in stool wet weigh results from a reduction in water content and reduction in the dry mass of stool output

behavior/neurological

behavior/neurological phenotype ( J:156741 )

♀N • mice show no motor abnormalities; rotarod latencies and distances traveled in open field tests are similar to controls at 6 and 12 months

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Parkinson's disease 1		DOID:0060367	OMIM:168601	J:156741