Phenotypes Associated with This Genotype

Genotype
MGI:4421497

cn10

• Allelic Composition: Cebpb^tm1.1Maka/Cebpb^tm1.1Maka; Ins2^Akita/Ins2^Akita; Tg(Ins2-cre)23Herr/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NSlc * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Abnormal glucose and insulin homeostasis in Ins2^Akita/Ins2^Akita and Ins2^Akita/Ins2^Akita Cebpb^tm1.1Maka/Cebpb^tm1.1Maka Tg(Ins2-cre)23Herr/0 but not Cebpb^tm1.1Maka/Cebpb^tm1.1Maka Tg(Ins2-cre)23Herr/0 mice.

endocrine/exocrine glands

abnormal pancreatic islet cell apoptosis ( J:156725 )

• expression of apoptosis markers in the pancreas islet is decreased compared to in Ins2^Akita homozygotes

abnormal pancreatic beta cell mass ( J:156725 )

• mice exhibit improved beta cell mass compared to in Ins2^Akita homozygotes

decreased insulin secretion ( J:156725 )

• pancreatic insulin levels are decreased compared to in wild-type mice

• however, pancreatic insulin content is 8-fold higher than in Ins2^Akita homozygotes

homeostasis/metabolism

decreased insulin secretion ( J:156725 )

• pancreatic insulin levels are decreased compared to in wild-type mice

• however, pancreatic insulin content is 8-fold higher than in Ins2^Akita homozygotes

increased circulating glucose level ( J:156725 )

• mice exhibit increased circulating glucose levels compared to in wild-type mice

• however, glucose serum level are increased compared to in Ins2^Akita homozygotes

decreased circulating insulin level ( J:156725 )

• mice exhibit decreased circulating glucose levels compared to in wild-type mice

• however, insulin serum level are increased compared to in Ins2^Akita homozygotes

cellular

abnormal pancreatic islet cell apoptosis ( J:156725 )

• expression of apoptosis markers in the pancreas islet is decreased compared to in Ins2^Akita homozygotes