Phenotypes Associated with This Genotype

Genotype
MGI:4421499

cn21

• Allelic Composition: Cebpb^tm1.1Maka/Cebpb^tm1.1Maka; Lepr^db/Lepr^db; Tg(Ins2-cre)23Herr/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BLKS/J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Increased beta cell mass in Lepr^db/Lepr^db mice and Lepr^db/Lepr^db Cebpb^tm1.1Maka/Cebpb^tm1.1Maka Tg(Ins2-cre)23Herr/0 mice

endocrine/exocrine glands

abnormal pancreatic islet cell apoptosis ( J:156725 )

• pancreatic islet cell apoptosis is decreased compared to in Lepr^db homozygotes

increased pancreatic beta cell mass ( J:156725 )

• compared to in Lepr^db homozygotes

homeostasis/metabolism

hyperglycemia ( J:156725 )

• hyperglycemia develops more slowly and is ameliorated compared to in Lepr^db homozygotes

increased circulating insulin level ( J:156725 )

• at 12 weeks, plasma insulin levels are increased compared to in Lepr^db homozygotes and wild-type mice

cellular

abnormal pancreatic islet cell apoptosis ( J:156725 )

• pancreatic islet cell apoptosis is decreased compared to in Lepr^db homozygotes