Phenotypes Associated with This Genotype

Genotype
MGI:4421776

• Allelic Composition: Cd74^tm1Anjm/Cd74⁺; Lmo2^tm2(cre)Thr/Lmo2⁺; Smim3^tm1Anjm/Smim3⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased granulocyte monocyte progenitor cell number ( J:155870 )

• a decrease in granulocyte/macrophage colony-forming units in spleen and bone marrow

• by flow cytometry, there is a reduced number of granulocyte-monocyte progenitors in the bone marrow

decreased erythroid progenitor cell number ( J:155870 )

• a decrease in erythroid colony-forming units in the bone marrow

decreased erythrocyte cell number ( J:155870 )

• there are a reduced numbers of circulating red blood cells

increased mean corpuscular volume ( J:155870 )

thrombocytopenia ( J:155870 )

decreased hematopoietic stem cell number ( J:155870 )

• in bone marrow and spleen

decreased megakaryocyte-erythroid progenitor cell number ( J:155870 )

• by flow cytometry, there is a reduced number of megakaryocytic-erythroid progenitors in the bone marrow

skeleton

abnormal bone marrow morphology ( J:155870 )

• bone marrow dysplasia

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chromosome 5q deletion syndrome		DOID:0090016	OMIM:153550	J:155870