Phenotypes Associated with This Genotype

Genotype
MGI:4429156

• Allelic Composition: Tg(GFAP-HTT*160Q)1Xjl/0
• Genetic Background: either: (involves: FVB/NCrl) or (involves: C3H * C57BL/6 * FVB/NCrl)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:156460 )

• mice die by 27 months

behavior/neurological

abnormal behavior ( J:156460 )

• behavioral phenotypes worsen with age

lethargy ( J:156460 )

• at 11 months

poor grooming ( J:156460 )

• at 11 months

limb grasping ( J:156460 )

impaired coordination ( J:156460 )

• after 13 months of age

hunched posture ( J:156460 )

nervous system

gliosis ( J:156460 )

• increases in aged mice

neurodegeneration ( J:156460 )

• mice older than 1.5 years exhibit increased GFAP staining in the brain compared with wild-type mice

growth/size/body

weight loss ( J:156460 )

• in mice 16 months or older

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Huntington's disease		DOID:12858	OMIM:143100	J:156460