Analysis Tools
behavior/neurological
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• female mice exhibit reduced total distance travelled, mean velocity, rearing, board entry, and hole exploration compared with wild-type mice
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• female mice exhibit increased energy uptake per unit body weight compared with wild-type mice
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• male mice exhibit decreased latencies to enter the board and explore the holes and increased latency to grooming compared with wild-type mice
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• female mice exhibit increased latency to enter the anxiogenic, exposed area (board entry) and increased risk assessment behavior, increased latency to explore the objects, and a tendency to stay more in contact with their cage mates in the adjacent group compartment compared with wild-type mice
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• in a von Frey test
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• mice exhibit decreased grip strength compared with wild-type mice
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• in a chemical-abdominal constriction test
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• in a Hargreaves test but not a tail flick test
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homeostasis/metabolism
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• in male mice
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• in female mice
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• in female mice
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• in female mice
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• in male mice
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• in male mice
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• female mice metabolize more energy per unit body weight compared with wild-type mice
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vision/eye
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• at E14.5, cornea are thickened compared to in wild-type mice and exhibits some adhesion to the rudimentary lens
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• at E14.5, the rudimentary lens exhibits some adhesion to the cornea unlike in wild-type mice
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• eyelids are closed at weaning
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• mice exhibit a hypertrophic retina that fills almost the entire vitreous body
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• retinal layers are inhomogeneous unlike in wild-type mice
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retina fold
(
J:156878
)
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• retina is folded unlike in wild-type mice
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immune system
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• decreased frequency in female mice
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• increased frequency in female mice
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• increased frequency in female mice
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• in male mice
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• unlike in wild-type mice, IgE levels are equivalent between male and female mice
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• in female mice
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respiratory system
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• male mice exhibit increased mean respiratory rates and decreased mean inspiratory flow, minute ventilation, inspiratory time, and tidal volume compared with wild-type mice
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• male mice exhibit increased mean respiratory rates and decreased mean inspiratory flow, minute ventilation, inspiratory time, and tidal volume compared with wild-type mice
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• mice exhibit more frequent but less effective breathing compared with wild-type mice
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growth/size/body
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• in female mice
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• in male and female mice
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• at 9 weeks
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adipose tissue
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• at 9 weeks, fat mass and content are reduced compared to in wild-type mice
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liver/biliary system
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• in some mice with female mice slightly more affected than male mice
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nervous system
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• mice have fewer mesencephalic dopaminergic (mDA) neurons than wild-type mice
• the majority of mDAs in the substantia nigra are lost
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skeleton
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• female mice exhibit decreased bone mineral density, bone mineral content and bone content compared with wild-type mice
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hematopoietic system
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• decreased frequency in female mice
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• in female mice
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• increased frequency in female mice
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• increased frequency in female mice
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• in male mice
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• unlike in wild-type mice, IgE levels are equivalent between male and female mice
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• in female mice
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Parkinson's disease | DOID:14330 |
OMIM:PS168600 |
J:156878 | |
