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Phenotypes Associated with This Genotype
Genotype
MGI:4429609
Allelic
Composition
Msh2tm1Htr/Msh2tm1Htr
Tap1tm1Hpl/Tap1tm1Hpl
Genetic
Background
involves: 129P2/OlaHsd * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msh2tm1Htr mutation (1 available); any Msh2 mutation (95 available)
Tap1tm1Hpl mutation (1 available); any Tap1 mutation (51 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• mice that survive beyond 30 weeks exhibit a multitude of tumors types (erythroid, intestine, skin, uterus, mammary gland, lung, intestine, and hereditary nonpolyposis colorectal cancer)
• 80% of mice that survive beyond 30 weeks develop Hereditary Nonpolyposis Colon Cancer (HNPCC) tumors
• in mice that survive beyond 30 weeks
• in mice that survive beyond 30 weeks
• in mice that survive beyond 30 weeks
• in mice that survive beyond 30 weeks

integument
• in mice that survive beyond 30 weeks
• in mice that survive beyond 30 weeks

reproductive system
• in mice that survive beyond 30 weeks

digestive/alimentary system
• 80% of mice that survive beyond 30 weeks develop Hereditary Nonpolyposis Colon Cancer (HNPCC) tumors

respiratory system
• in mice that survive beyond 30 weeks

endocrine/exocrine glands
• in mice that survive beyond 30 weeks

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Lynch syndrome DOID:3883 OMIM:PS120435
J:45433


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory