Phenotypes Associated with This Genotype

Genotype
MGI:4430189

• Allelic Composition: Fgfr2^tm2Ewj/Fgfr2⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal brain morphology ( J:156940 )

• 1 of 14 mice exhibit severe brain asymmetry unlike in wild-type mice

• 1 of 14 mice exhibit mild brain asymmetry unlike in wild-type mice

• rostrocaudal brain length in many mice is decreased compared to in wild-type mice

enlarged fourth ventricle ( J:156940 )

• in 2 of 14 mice

enlarged lateral ventricles ( J:156940 )

• in 1 of 14 mice

abnormal cerebral hemisphere morphology ( J:156940 )

• cerebral height in many mice is increased compared to in wild-type mice

• mice exhibit cerebral asymmetry to varying degrees compared with wild-type mice

abnormal corpus callosum morphology ( J:156940 )

• arched in 3 of 14 mice

skeleton

premature coronal suture closure ( J:156940 )

• at P0, mice exhibit variation in the pattern and degree of coronal suture closure compared with wild-type mice

• mice exhibit unilateral or bilateral coronal suture synostosis unlike wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
acrocephalosyndactylia		DOID:12960	OMIM:101200	J:156940