Phenotypes Associated with This Genotype

Genotype
MGI:4431029

• Allelic Composition: Prlr^tm1Cnp/Prlr^tm1Cnp
• Genetic Background: involves: 129/Sv * 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:85593 )

N • Background Sensitivity: on a predominantly 129/Sv background, male mice exhibit normal reproductive morphology and fertility

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:85593 )

N • Background Sensitivity: on a predominantly 129/Sv background, follicle stimulating hormone, luteinizing hormone, and testosterone plasma levels are normal

decreased thyroxine level ( J:101609 )

• serum-free T4 levels are lower than in wild-type mice

decreased body temperature ( J:101609 )

endocrine/exocrine glands

abnormal thyroid gland morphology ( J:101609 )

• at 2, 4, and 5 months of age, thyroid gland weight is increased compared to in wild-type mice

• mice exhibit an increase in mucus cell-like structures in the thyroid gland compared to in wild-type mice

increased thyroid carcinoma incidence ( J:101609 )

• mice develop medullary thyroid carcinomas unlike wild-type mice

neoplasm

increased thyroid carcinoma incidence ( J:101609 )

• mice develop medullary thyroid carcinomas unlike wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
familial medullary thyroid carcinoma		DOID:0050547	OMIM:155240	J:101609