mortality/aging
• mice die around 49 days of age
• no mice survive longer than 9 weeks
|
nervous system
microgliosis
(
J:157113
)
• at 7 weeks
|
astrocytosis
(
J:157113
)
behavior/neurological
• on a rotarod
|
growth/size/body
• at weaning
|
weight loss
(
J:157113
)
• at 7 weeks of age
|
homeostasis/metabolism
• mice exhibit an increase in unestrified cholesterol in the cerebellum compared with wild-type mice
|
cellular
• mice exhibit proliferation of foamy cells in the liver unlike wild-type mice
|
immune system
microgliosis
(
J:157113
)
hematopoietic system
microgliosis
(
J:157113
)
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
Niemann-Pick disease | DOID:14504 | J:157113 |