About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:4436744
Allelic
Composition
Npc1m1N/Npc1tm1.2Apl
Genetic
Background
B6.Cg-Npc1m1N/Npc1tm1.2Apl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Npc1m1N mutation (3 available); any Npc1 mutation (74 available)
Npc1tm1.2Apl mutation (0 available); any Npc1 mutation (74 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die around 49 days of age
• no mice survive longer than 9 weeks

nervous system

behavior/neurological
• on a rotarod

growth/size/body
• at weaning
• at 7 weeks of age

homeostasis/metabolism
• mice exhibit an increase in unestrified cholesterol in the cerebellum compared with wild-type mice

cellular
• mice exhibit proliferation of foamy cells in the liver unlike wild-type mice

immune system

hematopoietic system

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Niemann-Pick disease DOID:14504 J:157113


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory