Phenotypes Associated with This Genotype

Genotype
MGI:4436865

hm1

• Allelic Composition: Rnf19b^tm1Jkorn/Rnf19b^tm1Jkorn
• Genetic Background: B6.129S-Rnf19b^tm1Jkorn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

impaired natural killer cell mediated cytotoxicity ( J:157393 )

• in a chromium release assay of YAC-1 tumor target cells, DX5+ NK cells from the spleen have a 60% reduction in killing of target cells

• NK activity is increased by IL2 stimulation but not to the same level as wild-type mice

decreased interferon-gamma secretion ( J:157393 )

• in freshly isolated NK cells after co-culture with YAC-1 cells

• NK cells cultured in IL2 for 3 days before co-culture with YAC-1 cells produce a great deal less IFN-gamma

neoplasm

increased metastatic potential ( J:157393 )

• a greater incidence and larger size of lung metastasis in a B16 melanoma injection model

increased tumor growth/size ( J:157393 )

• larger tumor nodules in a B16 melanoma injection model

hematopoietic system

impaired natural killer cell mediated cytotoxicity ( J:157393 )

• in a chromium release assay of YAC-1 tumor target cells, DX5+ NK cells from the spleen have a 60% reduction in killing of target cells

• NK activity is increased by IL2 stimulation but not to the same level as wild-type mice