Phenotypes Associated with This Genotype

Genotype
MGI:4436912

• Allelic Composition: Vhl^tm1.1Wkr/Vhl⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal blood vessel morphology ( J:157369 )

• enlarged blood vessels in kidneys and adrenal glands at 12 months of age

renal/urinary system

kidney cortex cyst ( J:157369 )

• renal cortical microcysts found at 12 months

liver/biliary system

liver/biliary system phenotype ( J:157369 )

N • normal liver histology at 12 months

neoplasm

increased incidence of tumors by chemical induction ( J:157369 )

increased adenocarcinoma incidence ( J:157369 )

• adenocarcinoma

preneoplasia ( J:157369 )

• in kidney papillary cysts as a result of transplacental ENU mutagenesis

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:157369 )

growth/size/body

kidney cortex cyst ( J:157369 )

• renal cortical microcysts found at 12 months

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
von Hippel-Lindau disease		DOID:14175	OMIM:193300	J:157369