About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:4437297
Allelic
Composition		 Amhr2tm3(cre)Bhr/Amhr2+
Smad1tm2Rob/Smad1tm2Rob
Smad5tm1Huy/Smad5tm1Zuk
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amhr2tm3(cre)Bhr mutation (1 available); any Amhr2 mutation (29 available)
Smad1tm2Rob mutation (1 available); any Smad1 mutation (32 available)
Smad5tm1Huy mutation (0 available); any Smad5 mutation (23 available)
Smad5tm1Zuk mutation (1 available); any Smad5 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:157310 )
• 33% of mutant females survived to 32 weeks
• 50% survival at approximately 29 week of age

neoplasm
increased granulosa cell tumor incidence ( J:157310 )
• develop granulosa cell tumors early during sexual maturity (at least by 8 wk of age)
• tumor characteristic: lacked nuclear grooves, infrequently contained Call-Exner bodies, high mitotic index, increased serum Inhibin A and anti-Mullerian hormone (AMH) level
• AMH expression in primary tumors and tumor cells as they metastasize outside the ovary

homeostasis/metabolism

endocrine/exocrine glands
increased granulosa cell tumor incidence ( J:157310 )
• develop granulosa cell tumors early during sexual maturity (at least by 8 wk of age)
• tumor characteristic: lacked nuclear grooves, infrequently contained Call-Exner bodies, high mitotic index, increased serum Inhibin A and anti-Mullerian hormone (AMH) level
• AMH expression in primary tumors and tumor cells as they metastasize outside the ovary

reproductive system
increased granulosa cell tumor incidence ( J:157310 )
• develop granulosa cell tumors early during sexual maturity (at least by 8 wk of age)
• tumor characteristic: lacked nuclear grooves, infrequently contained Call-Exner bodies, high mitotic index, increased serum Inhibin A and anti-Mullerian hormone (AMH) level
• AMH expression in primary tumors and tumor cells as they metastasize outside the ovary

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
ovarian cancer DOID:2394 OMIM:167000
OMIM:607893
 J:157310

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory