Phenotypes Associated with This Genotype

Genotype
MGI:4437437

• Allelic Composition: Tg(Lrrk2*G2019S)2Yue/0
• Genetic Background: involves: C3H * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:157931 )

N • mice exhibit normal neuronal survival

decreased neurotransmitter release ( J:157931 )

• at 12 months, evoked dopamine release is 35% lower than in wild-type mice

• however, evoked dopamine release at 6 months is normal

abnormal neurotransmitter uptake ( J:157931 )

• at 12 months, dopmine uptake is slower than in wild-type mice

behavior/neurological

abnormal locomotor coordination ( J:157931 )

• at 12 months, mice exhibit less diagonal distance between front and hind limbs than Tg(Lrrk2)6Yue mice

short stride length ( J:157931 )

• compared with Tg(Lrrk2)6Yue mice at 12 months

homeostasis/metabolism

decreased dopamine level ( J:157931 )

• at 12 months, striatal dopamine levels are 25% lower than in wild-type mice

• however, striatal dopamine levels at 6 months are normal

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Parkinson's disease 8		DOID:0060371	OMIM:607060	J:157931