Phenotypes Associated with This Genotype

Genotype
MGI:4437475

• Allelic Composition: Cryaa^tm1Ady/Cryaa^tm1Ady
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Lens opacity in Cryaa^tm1Ady/Cryaa⁺, Cryaa^tm1Ady/Cryaa^tm1Ady, and Cryaa^tm1.1Ady/Cryaa^tm1.1Ady mice

vision/eye

ruptured lens capsule ( J:157274 )

• at 3 months, mice exhibit rupture of the posterior capsule unlike wild-type mice

abnormal lens fiber morphology ( J:157274 )

• at 3 weeks, lenses contain small and large swollen cells or vacuoles in the lens cortical fiber with gaps between fiber cells unlike in wild-type mice

• fiber cells detach from the capsule unlike in wild-type mice

• the number of swollen fiber cells increases with age

• at 10 months, large aberrant fibers cells are observed unlike in wild-type mice

cataract ( J:157274 )

• beginning prior to 2 months of age, near complete at 3 months of age, and complete at 5 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cataract 9 multiple types		DOID:0110266	OMIM:604219	J:157274