Phenotypes Associated with This Genotype

Genotype
MGI:4437476

• Allelic Composition: Cryaa^tm1Ady/Cryaa⁺
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Lens opacity in Cryaa^tm1Ady/Cryaa⁺, Cryaa^tm1Ady/Cryaa^tm1Ady, and Cryaa^tm1.1Ady/Cryaa^tm1.1Ady mice

vision/eye

abnormal lens morphology ( J:157274 )

• at 9 months, mice exhibit severe posterior rupture of the lens, curling up of the posterior capsule, and migration of cells to the posterior lens unlike wild-type mice

ruptured lens capsule ( J:157274 )

• at 9 months, mice exhibit severe posterior rupture of the lens unlike wild-type mice

abnormal lens fiber morphology ( J:157274 )

• at 3 weeks, lenses contain small and large swollen cells or vacuoles in the lens cortical fiber unlike in wild-type mice

cataract ( J:157274 )

• beginning at 2 to 3 months of age and worsening with age in the posterior and nuclear regions of the lens

nuclear cataract ( J:157274 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cataract 9 multiple types		DOID:0110266	OMIM:604219	J:157274