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Phenotypes Associated with This Genotype
Genotype
MGI:4437910
cx5
Allelic
Composition		 Ightm2Cgn/Ightm2Cgn
Igktm1Rsky/Igktm1Rsky
Lig4tm1Fwa/Lig4tm1Fwa
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm2Cgn mutation (1 available); any Igh mutation (39 available)
Igktm1Rsky mutation (1 available); any Igk mutation (27 available)
Lig4tm1Fwa mutation (2 available); any Lig4 mutation (46 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (244 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal class switch recombination ( J:126758 )
• class switching to IgG1 in B cells stimulated with anti-CD40 plus IL4 are 50% of wild-type

immune system
abnormal class switch recombination ( J:126758 )
• class switching to IgG1 in B cells stimulated with anti-CD40 plus IL4 are 50% of wild-type

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory