Phenotypes Associated with This Genotype

Genotype
MGI:4438035

• Allelic Composition: Tg(Myh6-rtTA)8585Jam/0; Tg(tetO-CUGBP1)3413Coop/0
• Genetic Background: involves: FVB * FVB/N * FVB/NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality ( J:157646 )

• following doxycycline treatment

cardiovascular system

myocardium necrosis ( J:157646 )

• following doxycycline treatment for 8 days

cardiac muscle degeneration ( J:157646 )

• following doxycycline treatment for 8 days

enlarged heart ( J:157646 )

• following doxycycline treatment

increased heart weight ( J:157646 )

• following doxycycline treatment

abnormal heart left ventricle morphology ( J:157646 )

• following doxycycline treatment, mice exhibit decreased posterior wall thickness during systole unlike in doxycycline-treated Tg(Myh6-rtTA)8585Jam mice

dilated heart left ventricle ( J:157646 )

• following doxycycline treatment, mice exhibit increased left ventricular dilation with left ventricular internal diameter in diastole and systole compared with doxycycline-treated Tg(Myh6-rtTA)8585Jam mice

dilated cardiomyopathy ( J:157646 )

• following doxycycline treatment for 8 days, mice exhibit dilated cardiomyopathy with widespread degeneration, necrosis, and loss of myocardial fibers unlike doxycycline-treated Tg(Myh6-rtTA)8585Jam mice

decreased cardiac muscle contractility ( J:157646 )

• following doxycycline treatment for 7 to 8 days, mice exhibit reduced ejection fraction compared with doxycycline-treated Tg(Myh6-rtTA)8585Jam mice

prolonged PR interval ( J:157646 )

• following doxycycline treatment

prolonged QRS complex duration ( J:157646 )

• following doxycycline treatment, QRS complex is prolonged compared to in doxycycline-treated Tg(Myh6-rtTA)8585Jam mice

behavior/neurological

lethargy ( J:157646 )

• 7 days after doxycycline treatment

muscle

myocardium necrosis ( J:157646 )

• following doxycycline treatment for 8 days

cardiac muscle degeneration ( J:157646 )

• following doxycycline treatment for 8 days

dilated cardiomyopathy ( J:157646 )

• following doxycycline treatment for 8 days, mice exhibit dilated cardiomyopathy with widespread degeneration, necrosis, and loss of myocardial fibers unlike doxycycline-treated Tg(Myh6-rtTA)8585Jam mice

decreased cardiac muscle contractility ( J:157646 )

• following doxycycline treatment for 7 to 8 days, mice exhibit reduced ejection fraction compared with doxycycline-treated Tg(Myh6-rtTA)8585Jam mice

growth/size/body

enlarged heart ( J:157646 )

• following doxycycline treatment

increased heart weight ( J:157646 )

• following doxycycline treatment

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
myotonic dystrophy type 1		DOID:11722	OMIM:160900	J:157646