Phenotypes Associated with This Genotype

Genotype
MGI:4438065

• Allelic Composition: Fbn2^mz/Fbn2^mz
• Genetic Background: involves: BALB/cAnNCrl * C3H/HeH

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Muscle weakness in Fbn2^mz/Fbn2^mz mice

muscle

decreased skeletal muscle fiber diameter ( J:157998 )

centrally nucleated skeletal muscle fibers ( J:157998 )

increased skeletal muscle mass ( J:157998 )

• in the soleus muscle

abnormal muscle electrophysiology ( J:157998 )

• at 4 months, peak isometric tetanic force is higher than in wild-type muscle cells

• however, peak isometric stress is normal

muscle weakness ( J:157998 )

• generalized

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:157998 )

• mice exhibit poor performance in the MoRAG test for measuring grasping and retrieval of food pellets compared with wild-type mice

limb grasping ( J:157998 )

decreased grip strength ( J:157998 )

• in the grip strength and wire maneuver tests

limbs/digits/tail

syndactyly ( J:157998 )

• with two or more adjacent toes on the hind limb paw

fused phalanges ( J:157998 )

growth/size/body

decreased body size ( J:157998 )

postnatal growth retardation ( J:157998 )

skeleton

fused phalanges ( J:157998 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
distal arthrogryposis		DOID:0050646	OMIM:PS108120	J:157998