Phenotypes Associated with This Genotype

Genotype
MGI:4438223

• Allelic Composition: Tg(ACTB-APP*V717F)1Colm/0
• Genetic Background: involves: C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

enhanced behavioral response to addictive substance ( J:157859 )

• amphetamine-treated mice exhibit increased hyperactivity compared with similarly treated wild-type mice

abnormal learning/memory/conditioning ( J:157859 )

• mice exhibit reduced alternation in a Y-maze compared with wild-type mice

impaired passive avoidance behavior ( J:157859 )

• mice exhibit reduced retention in a passive avoidance test compared with wild-type mice

behavioral despair ( J:157859 )

• young, but not old, mice exhibit increased immobility during a forced swim test compared with wild-type mice

increased startle reflex ( J:157859 )

• old, but not young, mice exhibit an increase in startle amplitude compared with wild-type mice

hyperactivity ( J:157859 )

• in young, but not old, mice exhibit increased activity in an open field test and entries in an elevated plus maze or Y-maze compared with wild-type mice

• at 9 months, mice exhibit slight hyperactivity compared with wild-type mice

• however, mice exhibit normal activity levels at 22 months

induced hyperactivity ( J:157859 )

• amphetamine-treated mice exhibit increased hyperactivity compared with similarly treated wild-type mice

nervous system

abnormal axon morphology ( J:157859 )

cellular

increased apoptosis ( J:157859 )

• in CA1 of the hippocampus

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:157859