Phenotypes Associated with This Genotype

Genotype
MGI:4438241

• Allelic Composition: Tg(HTT*)1Xwy/0
• Genetic Background: FVB-Tg(HTT*)1Xwy

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal forebrain morphology ( J:157723 )

• mice exhibit decreased forebrain weight compared with wild-type mice

decreased striatum size ( J:157723 )

• mice exhibit a 17% reduction in striatal volume compared with wild-type mice

abnormal cerebral cortex morphology ( J:157723 )

• mice exhibit a 17% reduction in cortical volume compared with wild-type mice

abnormal neuron morphology ( J:157723 )

• at 2 months, mice exhibit protein aggregates that worsen with age unlike in wild-type mice

• at 12 months, mice exhibit protein aggregates in the cortex and striatum unlike in wild-type mice

neuron degeneration ( J:157723 )

• at 12 months, mice exhibit selective neuropathy unlike wild-type mice

behavior/neurological

abnormal depression-related behavior ( J:157723 )

• at 12 months, mice exhibit depressive-like behavior unlike wild-type mice

increased anxiety-related response ( J:157723 )

• mice spend less time in the light portion of a light/dark box than wild-type mice

impaired coordination ( J:157723 )

• starting at 2 months and worsening with age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Huntington's disease		DOID:12858	OMIM:143100	J:157723