Phenotypes Associated with This Genotype

Genotype
MGI:4438359

• Allelic Composition: Mcph1^{Gt(RRO608)Byg}/Mcph1^{Gt(RRO608)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:157993 )

• difference in survival detectable after 65 weeks of age

premature death ( J:157993 )

• difference in survival detectable after 65 weeks of age

cellular

abnormal chromosome morphology ( J:157993 )

• primary fibroblasts show a dramatic increase of nuclei displaying condensed prophase-like chromatin

abnormal mitosis ( J:157993 )

• premature chromosome condensation and delayed decondensation in primary fibroblasts

reproductive system

reproductive system phenotype ( J:157993 )

N • in contrast to the defect in mitosis, no abnormalities in male meiosis are detected and both males and females are fertile

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
microcephaly		DOID:10907		J:157993