Phenotypes Associated with This Genotype

Genotype
MGI:4438361

cn3

• Allelic Composition: Bdnf^tm3Jae/Bdnf^tm3Jae; Tg(Cck-cre)CKres/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:157538 )

N • locomotor function, baseline startle response, pain sensitivity and prepulse inhibition are similar to controls

impaired cued conditioning behavior ( J:157538 )

• mice show robust attenuation of freezing when presented with the conditioned stimulus (tone) when tested for expression of previously learned fear

• mice show deficits in short- and long-term learning and memory to the conditioned cue, but display normal rate of extinction of conditioned fear

• 7,8-Dihydroxyflavone treatment rescues this impairment in cued fear conditioning