Phenotypes Associated with This Genotype

Genotype
MGI:4438371

cn2

• Allelic Composition: Bdnf^tm3Jae/Bdnf^tm3Jae
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:157538 )

N • locomotor activity, anxiety, and novel object recognition responses in animals receiving injections of a lentivirus-cre (LV-cre) in the prelimbic cortex are similar to controls

impaired cued conditioning behavior ( J:157538 )

• animals receiving injections of a LV-cre in the prelimbic cortex display normal acquisition and expression of newly acquired fear, but when retested for fear to the cue (tone), show significantly decreased freezing responses relative to controls