Phenotypes Associated with This Genotype

Genotype
MGI:4439299

• Allelic Composition: p23-ST1/p23-ST1
• Genetic Background: C57BL/6J-p23-ST1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

p23-ST1/p23-ST1 mice exhibit enlarged ventricles starting from the age of 1 month

nervous system

nervous system phenotype ( J:158278 )

N • mice exhibit normal intracranial pressure

microgliosis ( J:158278 )

• as early as 3 months and at 24 months in the lateral septal nucleus (dorsal and ventral), striatum, and cortex

non-obstructive hydrocephaly ( J:158278 )

increased brain size ( J:158278 )

• without an increase in brain weight

enlarged brain ventricles ( J:158278 )

• mice exhibit enlargement of the third and lateral ventricles that is detected at an early age and persists, with gradual progression, throughout life

• however, the fourth ventricle, cerebral aqueduct, and choroid plexus remain normal

enlarged lateral ventricles ( J:158278 )

enlarged third ventricle ( J:158278 )

abnormal cerebral hemisphere morphology ( J:158278 )

• at 18 and 24 months, the number of glial cells is increased and the number of neuronal cells is decreased with the dorsal lateral septal nucleus compared to in wild-type mice

astrocytosis ( J:158278 )

• at 24 months

decreased neuron number ( J:158278 )

• at 24 months in the dorsal lateral nucleus, medial septal nucleus, striatum and cortex

behavior/neurological

abnormal cued conditioning behavior ( J:158278 )

• in contextual and cued fear conditioning experiments mice exhibit shorter time to resume normal activity compared with wild-type mice indicating short-term and long-term memory deficits

impaired coordination ( J:158278 )

• mice exhibit poor performance on a rotarod (at 18 months) and more-frequent repetitive stumbling and shortened step length in a catwalk test (at 20 to 24 months) compared with wild-type mice

abnormal gait ( J:158278 )

• at 20 to 24 months, mice exhibit unsteady, wobbly swaying gait unlike wild-type mice

short stride length ( J:158278 )

• in a catwalk test at 20 to 24 months

renal/urinary system

increased urination frequency ( J:158278 )

• under mild stress

polyuria ( J:158278 )

• under mild stress

urinary incontinence ( J:158278 )

• under mild stress, mice exhibit increased urination frequency and volume compared with wild-type mice

immune system

microgliosis ( J:158278 )

• as early as 3 months and at 24 months in the lateral septal nucleus (dorsal and ventral), striatum, and cortex

hematopoietic system

microgliosis ( J:158278 )

• as early as 3 months and at 24 months in the lateral septal nucleus (dorsal and ventral), striatum, and cortex

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
normal pressure hydrocephalus		DOID:1572	OMIM:236690	J:158278