Phenotypes Associated with This Genotype

Genotype
MGI:4440540

tg1

• Allelic Composition: Tg(Thy1-Sncg)HvP36Putt/Tg(Thy1-Sncg)HvP36Putt
• Genetic Background: C57BL/6-Tg(Thy1-Sncg)HvP36Putt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:147580 )

• mice do not survive beyond 16 months

behavior/neurological

limb grasping ( J:147580 )

• at 6 to 9 months

abnormal motor coordination/balance ( J:147580 )

impaired righting response ( J:147580 )

• following paresis

impaired balance ( J:147580 )

• earlier than 6 months

impaired coordination ( J:147580 )

• earlier than 6 months

hunched posture ( J:147580 )

• at 6 to 9 months

abnormal gait ( J:147580 )

• at 6 to 9 months

short stride length ( J:147580 )

• at 6 months

paralysis ( J:147580 )

• following paresis

paresis ( J:147580 )

• at 9 to 16 months, mice develop paresis unlike wild-type mice with earlier development in forelimbs than in hindlimbs

nervous system

abnormal nervous system morphology ( J:147580 )

• mice exhibit aggregation and fibrillation of gamma-synuclein in the nervous system unlike wild-type mice

• abnormal gamma-synuclein structures are most abundant in the spinal cord

astrocytosis ( J:147580 )

• in the spinal cord gray matter of severely affected and older mice

decreased motor neuron number ( J:147580 )

• at 12 months, motor neuron numbers in severely affected mice are less than 40% of wild-type

• motor neuron loss corresponds to severity of motor impairment

homeostasis/metabolism

amyloidosis ( J:147580 )

• in the spinal cord or brain tissue when mild clinical signs of pathology are apparent

• the number of inclusions increases as clinical phenotypes worsen