Analysis Tools
behavior/neurological
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• mice develop motor dysfunction compared with wild-type mice with greater latency and slower progression than homozygous mice
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• after 18 months of age, mice exhibit impaired performance on a rotarod compared with wild-type mice
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• at 18 months, mice have shorter strides than wild-type mice
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nervous system
astrocytosis
(
J:147580
)
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• in older mice
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• motor neuron loss corresponds to severity of motor impairment
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homeostasis/metabolism
amyloidosis
(
J:147580
)
|
• in the spinal cord or brain tissue when mild clinical signs of pathology are apparent
• the number of inclusions increases as clinical phenotypes worsen
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