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Phenotypes Associated with This Genotype
Genotype
MGI:4440638
cx2
Allelic
Composition		 Sec24bY613X/Sec24b+
Vangl2Lp/Vangl2+
Genetic
Background		 involves: A * C3H/He * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sec24bY613X mutation (1 available); any Sec24b mutation (68 available)
Vangl2Lp mutation (2 available); any Vangl2 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, incomplete penetrance ( J:158452 )
• over 50% of mice die between late embryogenesis and four weeks of age
postnatal lethality, incomplete penetrance ( J:158452 )
• over 50% of mice die between late embryogenesis and four weeks of age

nervous system
spina bifida ( J:158452 )
• in 68% of mice

embryo
spina bifida ( J:158452 )
• in 68% of mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory