Analysis Tools
skeleton
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• as determined by marker expression, osteoblast differentiation at the chondro-osseuous junction and the metaphysis is increased compared to in wild-type mice
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• osteoblast proliferation at the chondro-osseuous junction and the metaphysis is increased compared to in wild-type mice
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• the suture between the horizontal plate of the palatine bone and palatal process of the maxilla is fused unlike in wild-type mice
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• coronal sutures exhibit increased osteogenic differentiation and accelerated bone growth compared to in wild-type mice
• however, apoptosis rates at coronal sutures is normal
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• the inter-premaxillary suture appears patent unlike in wild-type mice
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• mice exhibit premature closure of the premaxillary-maxillary sutures unlike wild-type mice
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• skull height is increased compared to in wild-type mice
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• mice exhibit shorter maxilla than wild-type and cre-recombined Fgfr2tm2Ewj heterozygotes
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• the nasal region is shorter than in wild-type mice
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• at P0, mice exhibit coronal suture presynostosis or synostosis unlike wild-type mice
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• mice exhibit premature closure of the suture between the zygomatic process of the maxilla and the zygomatic bones unlike wild-type mice
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craniofacial
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• the suture between the horizontal plate of the palatine bone and palatal process of the maxilla is fused unlike in wild-type mice
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• coronal sutures exhibit increased osteogenic differentiation and accelerated bone growth compared to in wild-type mice
• however, apoptosis rates at coronal sutures is normal
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• the inter-premaxillary suture appears patent unlike in wild-type mice
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• mice exhibit premature closure of the premaxillary-maxillary sutures unlike wild-type mice
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• skull height is increased compared to in wild-type mice
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• mice exhibit shorter maxilla than wild-type and cre-recombined Fgfr2tm2Ewj heterozygotes
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• the nasal region is shorter than in wild-type mice
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• the most posterior portion of the palate is reduced compared to in wild-type mice
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• the midline suture between the horizontal plates of the palatine bones is patent compared to controls
• in 1 of 8 mice the suture between the horizontal plate of the palatine bone and the palatal shelf of the maxilla is patent compared with 7 of 12 wild-type mice
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• mice exhibit shorter palate than wild-type and cre-recombined Fgfr2tm2Ewj heterozygotes
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digestive/alimentary system
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• the most posterior portion of the palate is reduced compared to in wild-type mice
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• the midline suture between the horizontal plates of the palatine bones is patent compared to controls
• in 1 of 8 mice the suture between the horizontal plate of the palatine bone and the palatal shelf of the maxilla is patent compared with 7 of 12 wild-type mice
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• mice exhibit shorter palate than wild-type and cre-recombined Fgfr2tm2Ewj heterozygotes
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cellular
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• as determined by marker expression, osteoblast differentiation at the chondro-osseuous junction and the metaphysis is increased compared to in wild-type mice
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• osteoblast proliferation at the chondro-osseuous junction and the metaphysis is increased compared to in wild-type mice
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vision/eye
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• intercanthal distance is reduced compared to in wild-type mice
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growth/size/body
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• the nasal region is shorter than in wild-type mice
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• the most posterior portion of the palate is reduced compared to in wild-type mice
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• the midline suture between the horizontal plates of the palatine bones is patent compared to controls
• in 1 of 8 mice the suture between the horizontal plate of the palatine bone and the palatal shelf of the maxilla is patent compared with 7 of 12 wild-type mice
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• mice exhibit shorter palate than wild-type and cre-recombined Fgfr2tm2Ewj heterozygotes
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respiratory system
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• the nasal region is shorter than in wild-type mice
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