Phenotypes Associated with This Genotype

Genotype
MGI:4440865

• Allelic Composition: Rab25^tm1Jrgo/Rab25^tm1Jrgo; Smad3^tm1Par/Smad3⁺
• Genetic Background: 129-Rab25^tm1Jrgo Smad3^tm1Par

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Colon tumor formation and neoplasia in Rab25^tm1Jrgo/Rab25^tm1Jrgo Smad3^tm1Par/Smad3⁺ mice

digestive/alimentary system

abnormal colon morphology ( J:158733 )

• the glandular atypia results in numerous mucin-filled cysts in one proximal colon tumor

colon polyps ( J:158733 )

• aberrant or dysplastic crypts, hyperplastic lesions, and adenomatous polyps

abnormal rectum morphology ( J:158733 )

• rectal tumor lesions in 80% of the mice

increased colon adenocarcinoma incidence ( J:158733 )

• large invasive tumor lesions in the proximal colonic mucosa in 80% of the mice

• the colonic epithelial tumors extend into and through the submucosa with neoplastic glands penetrating the muscle wall

neoplasm

increased colon adenocarcinoma incidence ( J:158733 )

• large invasive tumor lesions in the proximal colonic mucosa in 80% of the mice

• the colonic epithelial tumors extend into and through the submucosa with neoplastic glands penetrating the muscle wall

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
colorectal cancer		DOID:9256	OMIM:114500	J:158733