Phenotypes Associated with This Genotype

Genotype
MGI:4442333

• Allelic Composition: Pten^tm1.1Gle/Pten⁺
• Genetic Background: involves: 129S6/SvEvTac * Black Swiss * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased stomach tumor incidence ( J:158751 )

• increased coincidence of stomach tumors with prostate neoplasms

increased adrenal gland tumor incidence ( J:158751 )

• 51.6% of 9 month old mice develop proliferative lesions of the adrenal gland

increased thyroid tumor incidence ( J:158751 )

• 58.6% of 9 month old mice develop proliferative lesions of the thyroid

increased mammary gland tumor incidence ( J:158751 )

• increased coincidence of mammary tumor in females and intestinal lesions

• increased coincidence of mammary tumor in females and adrenal lesions

increased prostate gland tumor incidence ( J:158751 )

♂ • increased coincidence of stomach tumors with prostate neoplasms

increased lymphoma incidence ( J:158751 )

• 54.1% of 9 month old mice develop proliferative lesions of the lymph node

increased T cell derived lymphoma incidence ( J:158751 )

• 65.0% of 9 month old mice develop proliferative lesions of the thymus

reproductive system

increased prostate gland tumor incidence ( J:158751 )

♂ • increased coincidence of stomach tumors with prostate neoplasms

endometrium hyperplasia ( J:158751 )

♀ • proliferative lesions of the endometrium, simple hyperplasia and atypical hyperplasia

integument

increased mammary gland tumor incidence ( J:158751 )

• increased coincidence of mammary tumor in females and intestinal lesions

• increased coincidence of mammary tumor in females and adrenal lesions

endocrine/exocrine glands

increased adrenal gland tumor incidence ( J:158751 )

• 51.6% of 9 month old mice develop proliferative lesions of the adrenal gland

increased T cell derived lymphoma incidence ( J:158751 )

• 65.0% of 9 month old mice develop proliferative lesions of the thymus

increased thyroid tumor incidence ( J:158751 )

• 58.6% of 9 month old mice develop proliferative lesions of the thyroid

increased mammary gland tumor incidence ( J:158751 )

• increased coincidence of mammary tumor in females and intestinal lesions

• increased coincidence of mammary tumor in females and adrenal lesions

increased prostate gland tumor incidence ( J:158751 )

♂ • increased coincidence of stomach tumors with prostate neoplasms

digestive/alimentary system

increased stomach tumor incidence ( J:158751 )

• increased coincidence of stomach tumors with prostate neoplasms

immune system

increased T cell derived lymphoma incidence ( J:158751 )

• 65.0% of 9 month old mice develop proliferative lesions of the thymus

hematopoietic system

increased T cell derived lymphoma incidence ( J:158751 )

• 65.0% of 9 month old mice develop proliferative lesions of the thymus

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Cowden syndrome		DOID:6457	OMIM:PS158350	J:158751