Analysis Tools
hematopoietic system
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• in both the erythroid and megakaryocytic lineages
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• at E13.5, mice exhibit anemia unlike Gata1tm1Mym/Gata1tm1Mym Tg(Gata1)#Mym control mice
• however, mice recover from anemia by E15.5
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• average ploidy is reduced compared to in Gata1tm1Mym/Gata1tm1Mym Tg(Gata1)#Mym control mice
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• at P0 and P5, the number of megakaryocytes in the liver is increased compared to in Gata1tm1Mym/Gata1tm1Mym Tg(Gata1)#Mym control mice
• however, between P0 and P5 the number of megakaryocytes is normal in the spleen
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• at E18.5
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• at E12.5 and E15.5, mice exhibit hyperproliferative megakaryocyte progenitors compared with Gata1tm1Mym/Gata1tm1Mym Tg(Gata1)#Mym control mice
• cultured fetal livers from E15.5 and E18.5 mice produce more numerous smaller cells in a CFU-Mk assay compared to samples from fetal livers of control mice
• however, the numbers of CFU-Mk in E18.5 fetal livers is normal
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• at P0, abnormal red blood cells are found in blood smear including ones with nucleus and denatured cells unlike in Gata1tm1Mym/Gata1tm1Mym Tg(Gata1)#Mym control mice
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• at E13.5, erythroid differentiation as assessed by CD71 expression is severely disrupted compared to in Gata1tm1Mym/Gata1tm1Mym Tg(Gata1)#Mym control mice
• however, erythroid differentiation is normal by E15.5
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• at P0 and P21
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• at P0
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• at P0
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• megathrombocytes and blast-like cells with prominent Golgi area and poorly developed cytoplasmic granulation are observed unlike in Gata1tm1Mym/Gata1tm1Mym Tg(Gata1)#Mym control mice
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• at P0 and P5
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• at P0 but not P5
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immune system
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• at P0 but not P5
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| transient myeloproliferative syndrome | DOID:0060888 |
OMIM:159595 |
J:158252 | |
