Phenotypes Associated with This Genotype

Genotype
MGI:4452344

• Allelic Composition: Gnai2^tm1Lbi/Gnai2^tm1Lbi
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

colitis ( J:91100 )

• Background Sensitivity: mutants on a mixed 129S7/SvEvBrd and C57BL/6 genetic background develop colitis between 12-25 weeks of age, resembling human ulcerative colitis

immune system

colitis ( J:91100 )

• Background Sensitivity: mutants on a mixed 129S7/SvEvBrd and C57BL/6 genetic background develop colitis between 12-25 weeks of age, resembling human ulcerative colitis

abnormal cytokine secretion ( J:91100 )

• production of pro-inflammatory cytokines, TNF and IL-1beta, and the Th1 promoting cytokine IL-12p40, are increased in response to formalin-killed Saphylococcus aureus and in response to superantigen stimulation via toxic shock syndrome toxin-1

increased interleukin-1 beta secretion ( J:91100 )

• in response to formalin-killed Saphylococcus aureus and toxic shock syndrome toxin-1

increased tumor necrosis factor secretion ( J:91100 )

• in response to formalin-killed Saphylococcus aureus and toxic shock syndrome toxin-1

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
inflammatory bowel disease 12		DOID:0110887	OMIM:612241	J:91100