Phenotypes Associated with This Genotype

Genotype
MGI:4454331

• Allelic Composition: Tg(Fabp4-LMNA*R482Q)11ACdl/0
• Genetic Background: FVB-Tg(Fabp4-LMNA*R482Q)11ACdl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Reduction in epididymal white fat pads and brown subscapular fat pads, and enlarged lipid droplets in Tg(Fabp4-LMNA*R482Q)11ACdl/0 mice

adipose tissue

decreased brown adipose tissue amount ( J:149858 )

• in the subscapular brown adipose fat pad when fed a high fat diet

decreased total body fat amount ( J:149858 )

• after 14 weeks of age when fed a high fat diet

• 59% less at 63 weeks when fed a high fat diet

• after 28 week weeks of age when fed standard chow

abnormal fat cell morphology ( J:149858 )

• when fed a high fat diet, fat cells exhibit less cell size uniformity compared to in similarly treated wild-type mice

increased brown fat cell lipid droplet size ( J:149858 )

• with unilocular deposition when fed a high fat diet

abnormal epididymal fat pad morphology ( J:149858 )

• leukocyte infiltration when mice are fed a high fat diet

decreased epididymal fat pad weight ( J:149858 )

• when fed a high fat diet

decreased renal fat pad weight ( J:149858 )

• when fed a high fat diet

decreased retroperitoneal fat pad weight ( J:149858 )

• when fed a high fat diet

decreased adipocyte glucose uptake ( J:149858 )

• >30% less glucose uptake in WAT when fed a high fat diet

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:149858 )

• when fed a high fat diet

abnormal glucose homeostasis ( J:149858 )

• when fed a high fat diet, mice exhibit altered insulin sensitivity in the liver, muscle, and white adipose tissues compared with similarly treated wild-type mice

increased circulating glucose level ( J:149858 )

• moderately when fed a high fat diet

• in a glucose tolerance test at week 22 when fed a high fat diet

increased circulating insulin level ( J:149858 )

• by week 18 when fed a high fat diet

decreased glycogen catabolism rate ( J:149858 )

• when fed a high fat diet

insulin resistance ( J:149858 )

• when fed a high fat diet

growth/size/body

increased lean body mass ( J:149858 )

• as a percentage of body weight when fed a high fat diet

decreased susceptibility to diet-induced obesity ( J:149858 )

• when fed a high fat diet

muscle

muscle phenotype ( J:149858 )

N • unlike patients with FPLD2, mice do not exhibit robust skeletal muscle hypertrophy

decreased muscle cell glucose uptake ( J:149858 )

• 25% less glucose uptake in muscle when fed a high fat diet

cellular

decreased adipocyte glucose uptake ( J:149858 )

• >30% less glucose uptake in WAT when fed a high fat diet

decreased muscle cell glucose uptake ( J:149858 )

• 25% less glucose uptake in muscle when fed a high fat diet

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
familial partial lipodystrophy		DOID:0050440	OMIM:PS151660	J:149858