Analysis Tools
homeostasis/metabolism
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• extracts of whole eyes collected immediately after exposure to 12,000 lux for 5 mins contain significantly lower levels of all trans-retinol than in wild-type
• however, no difference is detected at 1 h after light exposure
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• exposure to 12,000 lux of light for 5 min leads to visible bleaching of the entire retina for 1 h following exposure, in contrast wild-type retinas are unaffected
• exposure to 12,000 lux for 2 or more minutes induces photoreceptor degeneration
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vision/eye
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• TUNEL+ photoreceptors
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• exposure to 12,000 lux of light for 5 min leads to visible bleaching of the entire retina for 1 h following exposure, in contrast wild-type retinas are unaffected
• exposure to 12,000 lux for 2 or more minutes induces photoreceptor degeneration
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• the border between the outer and inner segments of the retina, and both compartments are highly disorganized 24 h after exposure to 12,000 lux of bright light
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• slightly shorter at 1 year of age
• 1 h after exposure to 12,000 lux of bright light, appear disorganized and some areas are devoid of outer segments, whereas others appear to contain outer segment aggregates
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• the border between the outer and inner segments of the retina, and both compartments are highly disorganized 24 h after exposure to 12,000 lux of bright light
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• bright light-induced degeneration of photoreceptors
• exposure to 12,000 lux for 2 or more minutes induces photoreceptor degeneration
• however, under standard housing conditions no degeneration is detected
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• after exposure to 12,000 lux of bright light, apical processes of retinal pigment epithelium that normally ensheath the outer segments appear to extend further along the outer segments than in wild-type
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• 24 h after exposure to 12,000 lux of bright light the outer nuclear layer appears disorganized, although cell loss is not apparent
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• two or fewer layers of photoreceptor nuclei remaining at 1 week following light exposure
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• mice recover with a time constant of 9.5 min and reach an asymptote that is only 60% of the dark adapted value
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nervous system
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• the border between the outer and inner segments of the retina, and both compartments are highly disorganized 24 h after exposure to 12,000 lux of bright light
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• slightly shorter at 1 year of age
• 1 h after exposure to 12,000 lux of bright light, appear disorganized and some areas are devoid of outer segments, whereas others appear to contain outer segment aggregates
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• the border between the outer and inner segments of the retina, and both compartments are highly disorganized 24 h after exposure to 12,000 lux of bright light
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• bright light-induced degeneration of photoreceptors
• exposure to 12,000 lux for 2 or more minutes induces photoreceptor degeneration
• however, under standard housing conditions no degeneration is detected
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pigmentation
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• after exposure to 12,000 lux of bright light, apical processes of retinal pigment epithelium that normally ensheath the outer segments appear to extend further along the outer segments than in wild-type
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cellular
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• TUNEL+ photoreceptors
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| retinitis pigmentosa 4 | DOID:0110372 |
OMIM:613731 |
J:159523 | |
