About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:4455027
Allelic
Composition		 RhoTvrm4/Rho+
Rpe65rd12/Rpe65rd12
Genetic
Background		 B6.Cg-Rpe65rd12 RhoTvrm4
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
RhoTvrm4 mutation (2 available); any Rho mutation (51 available)
Rpe65rd12 mutation (1 available); any Rpe65 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Photoreceptor degeneration without exposure to bright light in Rpe65rd12/Rpe65rd12 RhoTvrm4/Rho+ mice

vision/eye
retina photoreceptor degeneration ( J:159523 )
• photoreceptor degeneration without exposure to bright light
• the peripheral retina also shows cell loss but is better preserved than the central retina
retina outer nuclear layer degeneration ( J:159523 )
• at 4 weeks of age, retinas have only 2-3 rows of cell bodies remaining in the central outer nuclear layer

nervous system
retina photoreceptor degeneration ( J:159523 )
• photoreceptor degeneration without exposure to bright light
• the peripheral retina also shows cell loss but is better preserved than the central retina

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
retinitis pigmentosa DOID:10584 OMIM:PS268000
 J:159523

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory