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Phenotypes Associated with This Genotype
Genotype
MGI:4455028
Allelic
Composition		 RhoTvrm1/Rho+
Rpe65rd12/Rpe65rd12
Genetic
Background		 B6.Cg-Rpe65rd12 RhoTvrm1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
RhoTvrm1 mutation (1 available); any Rho mutation (51 available)
Rpe65rd12 mutation (1 available); any Rpe65 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
retina photoreceptor degeneration ( J:159523 )
• photoreceptor degeneration without exposure to bright light
• the peripheral retina also shows cell loss but is better preserved than the central retina
retina outer nuclear layer degeneration ( J:159523 )
• at 4 weeks of age, retinas have only 5 rows of cell bodies remaining in the central outer nuclear layer

nervous system
retina photoreceptor degeneration ( J:159523 )
• photoreceptor degeneration without exposure to bright light
• the peripheral retina also shows cell loss but is better preserved than the central retina

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
retinitis pigmentosa DOID:10584 OMIM:PS268000
 J:159523

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory