Phenotypes Associated with This Genotype

Genotype
MGI:4456472

• Allelic Composition: Gstm1^tm1Gcw/Gstm1^tm1Gcw
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal behavioral response to xenobiotic ( J:159701 )

• valproic acid (VPA) treatment reduces crawl-under social play behavior unlike in similarly treated wild-type mice

• VPA fails to decrease allogrooming or paired horizontal movement unlike in similarly treated wild-type mice

decreased locomotor activity ( J:159701 )

• mice exhibit decreased paired horizontal movement compared with wild-type mice

increased locomotor activity ( J:159701 )

• VPA-treated mice exhibit increased paired horizontal movement than similarly treated wild-type mice

abnormal social/conspecific interaction behavior ( J:159701 )

• mice exhibit increased crawl-under social play behavior compared with wild-type mice

• VPA-treated mice exhibit less crawl-under social play behavior than similarly treated wild-type mice

• following treatment with sodium valproate at P14, female mice exhibit decreased allogrooming compared with wild-type female

• however, allogrooming in female and male mice is the same as in wild-type male mice

nervous system

increased neuron apoptosis ( J:159701 )

• female mice exhibit increased VPA-induced granule cell apoptosis in the cerebellum and hippocampus compared with wild-type female

• however, levels of apoptosis in female and male mice are the same as in wild-type male mice

homeostasis/metabolism

increased dopamine level ( J:159701 )

• mice exhibit increased cerebellum dopamine levels compared with wild-type mice

• male mice exhibit increased frontal cortex dopamine levels regardless of VPA treatment compared with similarly treated wild-type mice

• however, VPA treatment increases dopamine to levels observed in similarly treated wild-type mice

increased serotonin level ( J:159701 )

• mice exhibit increased cerebellum serotonin levels compared with wild-type mice

• however, VPA treatment lowers cerebellum serotonin levels

abnormal physiological response to xenobiotic ( J:159701 )

• VPA treatment decreases cerebellum serotonin levels unlike in similarly treated wild-type mice

• however, VPA treatment lowers cerebellum serotonin levels and increases dopamine to levels observed in similarly treated wild-type mice

cellular

increased neuron apoptosis ( J:159701 )

• female mice exhibit increased VPA-induced granule cell apoptosis in the cerebellum and hippocampus compared with wild-type female

• however, levels of apoptosis in female and male mice are the same as in wild-type male mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder		DOID:0060041		J:159701