Phenotypes Associated with This Genotype

Genotype
MGI:4457497

• Allelic Composition: Sav1^tm2.1Dlim/Sav1^tm2.1Dlim; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
• Genetic Background: involves: C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

liver/biliary system phenotype ( J:160325 )

N • liver function is normal and liver regeneration

abnormal liver morphology ( J:160325 )

• mice exhibit regions of abnormal morphology with irregular and enlarged hepatocytes unlike wild-type mice

• however, gross hepatic architecture is normal

enlarged liver ( J:160325 )

• in mice fed a diet supplemented with 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DCC) for 6 weeks

increased liver weight ( J:160325 )

• in mice fed a diet supplemented with 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DCC)

abnormal hepatocyte morphology ( J:160325 )

• mice exhibit regions of abnormal morphology with irregular and enlarged hepatocytes unlike wild-type mice

• however, mice exhibit normal maturation and differentiation of hepatocytes

abnormal portal lobule morphology ( J:160325 )

• mice fed a diet supplemented with 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DCC) for 2 to 4 weeks exhibit changes in the portal tract region unlike similarly treated wild-type mice

increased hepatocellular carcinoma incidence ( J:238319 )

• mice develop hepatocellular carcinoma; tumors show abundant feeding arteries but no portal venous perfusion

increased hepatoma incidence ( J:160325 )

• by 12 months of age

abnormal oval cell morphology ( J:160325 )

• by 6 months, mice exhibit an increase in the number of immature progenitor or oval-like cells in the liver compared with wild-type mice

• mice fed a diet supplemented with 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DCC) exhibit an increase in oval cells compared with similarly treated wild-type mice

abnormal oval cell physiology ( J:160325 )

• at 3 to 12 months, more proliferating oval cells are observed than in wild-type mice

• mice fed a diet supplemented with 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DCC) exhibit an increase in proliferating oval cells compared with similarly treated wild-type mice

• oval cells from mice fed a diet supplemented with DCC exhibit increased proliferative capacity compared with cells isolated from similarly treated wild-type mice

neoplasm

increased hepatocellular carcinoma incidence ( J:238319 )

• mice develop hepatocellular carcinoma; tumors show abundant feeding arteries but no portal venous perfusion

increased hepatoma incidence ( J:160325 )

• by 12 months of age

growth/size/body

enlarged liver ( J:160325 )

• in mice fed a diet supplemented with 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DCC) for 6 weeks

increased liver weight ( J:160325 )

• in mice fed a diet supplemented with 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DCC)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hepatocellular carcinoma		DOID:684	OMIM:114550	J:238319