Phenotypes Associated with This Genotype

Genotype
MGI:4459447

• Allelic Composition: Rb1^tm3Tyj/Rb1^tm3Tyj; Rbl2^tm2Tyj/Rbl2^tm2Tyj; Trp53^tm1Brn/Trp53^tm1Brn
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:160148 )

• adeno-cre-treated mice begin to die at 17 weeks and by 6 months all mice are moribund

neoplasm

increased lung tumor incidence ( J:160148 )

• 3 and 6 months, adeno-cre-treated mice exhibit primary lung tumors with metastasis to the liver unlike wild-type mice

• at 3 and 6 month, adeno-cre-treated mice exhibit more tumors than in similarly treated Rb1^tm3Tyj Trp53^tm1Brn homozygotes

• adeno-cre-treated mice exhibit few lung adenocarcinomas, adenocarcinomas with neuroendocrine features, large-cell neuroendocrine carcinoma, and large-cell carcinomas while most tumors resemble neuroendocrine small-cell lung tumors

increased lung small cell carcinoma incidence ( J:160148 )

• most tumors in adeno-cre-treated mice resemble those found in human neuroendocrine small cell lung cancer patients

respiratory system

increased lung tumor incidence ( J:160148 )

• 3 and 6 months, adeno-cre-treated mice exhibit primary lung tumors with metastasis to the liver unlike wild-type mice

• at 3 and 6 month, adeno-cre-treated mice exhibit more tumors than in similarly treated Rb1^tm3Tyj Trp53^tm1Brn homozygotes

• adeno-cre-treated mice exhibit few lung adenocarcinomas, adenocarcinomas with neuroendocrine features, large-cell neuroendocrine carcinoma, and large-cell carcinomas while most tumors resemble neuroendocrine small-cell lung tumors

increased lung small cell carcinoma incidence ( J:160148 )

• most tumors in adeno-cre-treated mice resemble those found in human neuroendocrine small cell lung cancer patients

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lung small cell carcinoma		DOID:5409	OMIM:182280	J:160148