Phenotypes Associated with This Genotype

Genotype
MGI:4460266

• Allelic Composition: Msh2^tm2.1Rak/Msh2^tm2.1Rak; Tg(Vil1-cre)20Syr/0
• Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:161577 )

• all mice die by 17 months of age

neoplasm

increased gastrointestinal tumor incidence ( J:161577 )

• 89% of mice develop small intestine tumors compared with 6% of wild-type mice

• 50% of small intestine tumors are adenomas while the rest are highly invasive adenocarcinomas

increased small intestine adenocarcinoma incidence ( J:161577 )

• 50% of small intestine tumors are highly invasive adenocarcinomas

increased intestinal adenoma incidence ( J:161577 )

• 50% of small intestine tumors are adenomas

increased lymphoma incidence ( J:161577 )

• in only 1 of 150 mice

homeostasis/metabolism

abnormal mismatch repair ( J:161577 )

• intestinal epithelial cells exhibit an increase in microsatellite instability compared with wild-type cells

• tumor cells exhibit increased microsatellite instability compared with wild-type cells

cellular

abnormal mismatch repair ( J:161577 )

• intestinal epithelial cells exhibit an increase in microsatellite instability compared with wild-type cells

• tumor cells exhibit increased microsatellite instability compared with wild-type cells

digestive/alimentary system

increased gastrointestinal tumor incidence ( J:161577 )

• 89% of mice develop small intestine tumors compared with 6% of wild-type mice

• 50% of small intestine tumors are adenomas while the rest are highly invasive adenocarcinomas

increased small intestine adenocarcinoma incidence ( J:161577 )

• 50% of small intestine tumors are highly invasive adenocarcinomas

increased intestinal adenoma incidence ( J:161577 )

• 50% of small intestine tumors are adenomas

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Lynch syndrome		DOID:3883	OMIM:PS120435	J:161577