Phenotypes Associated with This Genotype

Genotype
MGI:4461031

• Allelic Composition: Tg(Igh-V-CD40lg)#Tsub/0
• Genetic Background: C57BL/6-Tg(Igh-V-CD40lg)#Tsub

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased anti-double stranded DNA antibody level ( J:128824 )

• one-third to one-half of 12- to 14-mo-old mice show production of autoantibodies

increased anti-histone antibody level ( J:128824 )

• one-third to one-half of 12- to 14-mo-old mice show production of autoantibodies

increased anti-single stranded DNA antibody level ( J:128824 )

• one-third to one-half of 12- to 14-mo-old mice show production of autoantibodies

glomerulonephritis ( J:128824 )

• approximately half of mice have a diffuse deposition of PAS-positive substance and hypercellularity in glomeruli

homeostasis/metabolism

increased urine protein level ( J:128824 )

• the level of urine protein is elevated in 12- to 14-mo-old

renal/urinary system

increased urine protein level ( J:128824 )

• the level of urine protein is elevated in 12- to 14-mo-old

glomerulonephritis ( J:128824 )

• approximately half of mice have a diffuse deposition of PAS-positive substance and hypercellularity in glomeruli

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
systemic lupus erythematosus		DOID:9074	OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420	J:128824