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Phenotypes Associated with This Genotype
Genotype
MGI:4461061
Allelic
Composition		 Mogtm1(cre)Gkl/Mogtm1(cre)Gkl
Tg(Tcra2D2,Tcrb2D2)1Kuch/0
Genetic
Background		 C57BL/6-Mogtm1(cre)Gkl Tg(Tcra2D2,Tcrb2D2)1Kuch
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mogtm1(cre)Gkl mutation (1 available); any Mog mutation (58 available)
Tg(Tcra2D2,Tcrb2D2)1Kuch mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to experimental autoimmune encephalomyelitis ( J:151335 )
• between 15% and 20% of mice develop spontaneous EAE

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
multiple sclerosis DOID:2377 OMIM:612594
OMIM:612595
OMIM:612596
 J:151335

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory