Phenotypes Associated with This Genotype

Genotype
MGI:4461136

• Allelic Composition: Tg(Tnf)6074Gkl/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal microglial cell morphology ( J:106592 )

• at 1 week of age there is widespread microglial activation

• at 8-10 weeks plaque edge cells contain myelin degradation products

abnormal astrocyte morphology ( J:106592 )

• at 8-10 weeks of age some astroglial scarring

abnormal meninges morphology ( J:106592 )

• minimal blood-brain barrier damage and immune infiltration can be observed at the meninges at 1 week of age

• at 4 weeks of age pronounced inflammation at the brain meninges

axon degeneration ( J:106592 )

• at 8-10 weeks of age moderate axonal damage is evident within plaques

abnormal nervous system physiology ( J:106592 )

• at 1 week of age TUNEL+ cells characteristic of apoptosis are found in the corpus callosum

impaired blood-brain barrier function ( J:106592 )

• at 8-10 weeks of age signs of BBB leakage

abnormal oligodendrocyte apoptosis ( J:106592 )

• oligodendrocyte apoptosis starting at 1 week of age

brain inflammation ( J:106592 )

• T lymphocyte infiltration in the cerebellum at 8-10 weeks of age

demyelination ( J:106592 )

• early demyelinating events consisting of myelin swelling and the formation of vacuoles with single fiber degeneration at 4 weeks of age

• by 8-10 weeks of age confluent symmetrical plaques of primary demyelination develop within the cerebellar white matter, the capsula interna and to a minor degree, the optic tracts

hematopoietic system

abnormal microglial cell morphology ( J:106592 )

• at 1 week of age there is widespread microglial activation

• at 8-10 weeks plaque edge cells contain myelin degradation products

immune system

abnormal microglial cell morphology ( J:106592 )

• at 1 week of age there is widespread microglial activation

• at 8-10 weeks plaque edge cells contain myelin degradation products

brain inflammation ( J:106592 )

• T lymphocyte infiltration in the cerebellum at 8-10 weeks of age

cardiovascular system

impaired blood-brain barrier function ( J:106592 )

• at 8-10 weeks of age signs of BBB leakage

cellular

abnormal oligodendrocyte apoptosis ( J:106592 )

• oligodendrocyte apoptosis starting at 1 week of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
multiple sclerosis		DOID:2377	OMIM:612594 OMIM:612595 OMIM:612596	J:106592