Phenotypes Associated with This Genotype

Genotype
MGI:4461138

• Allelic Composition: Tg(Gfap-TNF*)K21Gkl/0; Tnfrsf1a^tm1Blt/Tnfrsf1a⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal nervous system physiology ( J:106592 )

• neurological symptoms by the sixth month of age, delayed compared to Tg alone

demyelination ( J:106592 )

• at 6 months CNS shows symmetrical, focal demyelinated plaques at the capsula interna and in the spinal cord

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
multiple sclerosis		DOID:2377	OMIM:612594 OMIM:612595 OMIM:612596	J:106592