Phenotypes Associated with This Genotype

Genotype
MGI:4461139

• Allelic Composition: Tg(Tnf)6074Gkl/0; Tnfrsf1b^tm1Mwm/Tnfrsf1b^tm1Mwm
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal oligodendrocyte apoptosis ( J:106592 )

• in 4 week old mice

CNS inflammation ( J:106592 )

• in 4 week old mice

demyelination ( J:106592 )

• cerebellum myelin vacuolation in 4 week old mice

immune system

CNS inflammation ( J:106592 )

• in 4 week old mice

cellular

abnormal oligodendrocyte apoptosis ( J:106592 )

• in 4 week old mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
multiple sclerosis		DOID:2377	OMIM:612594 OMIM:612595 OMIM:612596	J:106592