Phenotypes Associated with This Genotype

Genotype
MGI:4461155

• Allelic Composition: Nrcam^tm1Gmt/Nrcam^tm1Gmt
• Genetic Background: involves: 129S6/SvEvTac * Swiss Webster

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal learning/memory/conditioning ( J:153165 )

• males and females display a longer latency to reach the escape platform in the reversal phase

abnormal motor learning ( J:153165 )

• in a rotarod test females, but not males, show a shorter latency to fall in retests suggesting an impairment in the improvement normally seen across trials

abnormal spatial learning ( J:153165 )

• females but not males display a longer latency to find a hidden platform

abnormal locomotor activation ( J:153165 )

• in a 1 h open field test females display decreased activity during the beginning of the test and increased activity towards the end of the test relative to control females

decreased vertical activity ( J:153165 )

• decrease in rearing frequency in an open field in females

abnormal social investigation ( J:153165 )

• males fail to show a preference for a stranger mouse over an empty cage

nervous system

decreased prepulse inhibition ( J:153165 )

• small but significant decrease in males

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder		DOID:0060041		J:153165