Phenotypes Associated with This Genotype

Genotype
MGI:4461160

• Allelic Composition: Tnfrsf1a^tm2.1Rsie/Tnfrsf1a⁺
• Genetic Background: B6.Cg-Tnfrsf1a^tm2.1Rsie

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:160543 )

• mice treated with 5 ng/g LPS and D-galactosamine exhibit increased mortality unlike similarly treated wild-type mice

• Background Sensitivity: mice on a C57BL/6 background are less sensitive to LPS and D-galactosamine than mice on a 129S6 background

• however, mortality at 10 ng/g LPS and D-galactosamine is normal

immune system

abnormal macrophage physiology ( J:160543 )

• TNF-stimulated peritoneal macrophages produce less IL6 than similarly treated wild-type cells

decreased circulating interleukin-1 beta level ( J:160543 )

• following LPS challenge

decreased circulating interleukin-6 level ( J:160543 )

• following LPS challenge

decreased interleukin-6 secretion ( J:160543 )

• TNF-stimulated peritoneal macrophages produce less IL6 than similarly treated wild-type cells

increased interleukin-6 secretion ( J:160543 )

• LPS-stimulated mouse embryonic fibroblasts exhibit increased IL6 secretion that is enhanced by application of TNFR2-Fc compared with similarly treated wild-type cells

increased susceptibility to endotoxin shock ( J:160543 )

• mice treated with LPS and D-galactosamine exhibit increased mortality unlike similarly treated wild-type mice

• Background Sensitivity: mice on a C57BL/6 background are less sensitive to LPS and D-galactosamine than mice on a 129S6 background

• however, mortality at 10 ng/g LPS and D-galactosamine is normal

homeostasis/metabolism

decreased circulating interleukin-1 beta level ( J:160543 )

• following LPS challenge

decreased circulating interleukin-6 level ( J:160543 )

• following LPS challenge

hematopoietic system

abnormal macrophage physiology ( J:160543 )

• TNF-stimulated peritoneal macrophages produce less IL6 than similarly treated wild-type cells

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autosomal dominant familial periodic fever		DOID:0090018	OMIM:142680	J:160543