Phenotypes Associated with This Genotype

Genotype
MGI:4461165

• Allelic Composition: Tnfrsf1a^tm1Rsie/Tnfrsf1a⁺
• Genetic Background: B6.Cg-Tnfrsf1a^tm1Rsie

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:160543 )

• mice treated with 5 ng/g LPS and D-galactosamine exhibit increased mortality unlike similarly treated wild-type mice

• however, mortality at 10 ng/g LPS and D-galactosamine is normal

immune system

increased circulating tumor necrosis factor level ( J:160543 )

• following LPS challenge

increased interleukin-6 secretion ( J:160543 )

• LPS-stimulated mouse embryonic fibroblasts exhibit increased IL6 secretion that is enhanced by application of TNFR2-Fc compared with similarly treated wild-type cells

increased susceptibility to endotoxin shock ( J:160543 )

• mice treated with LPS and D-galactosamine exhibit increased mortality unlike similarly treated wild-type mice

• however, mortality at 10 ng/g LPS and D-galactosamine is normal

• LPS-treated mice exhibit exaggerated and prolonged temperature drop compared with similarly treated wild-type mice

homeostasis/metabolism

impaired adaptive thermogenesis ( J:160543 )

• LPS-treated mice exhibit exaggerated and prolonged temperature drop compared with similarly treated wild-type mice

increased circulating tumor necrosis factor level ( J:160543 )

• following LPS challenge

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autosomal dominant familial periodic fever		DOID:0090018	OMIM:142680	J:160543