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Phenotypes Associated with This Genotype
Genotype
MGI:4461249
cn8
Allelic
Composition		 Artm2Ska/Y
Gli1tm3(cre/ERT2)Alj/Gli1+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Artm2Ska mutation (0 available); any Ar mutation (23 available)
Gli1tm3(cre/ERT2)Alj mutation (2 available); any Gli1 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal external male genitalia morphology ( J:148515 )
• tamoxifen-treated mice exhibit hypoplastic external genitalia compared with wild-type mice
• external genitalis of tamoxifen-treated mice are feminized
abnormal foreskin morphology ( J:148515 )
• underdeveloped in tamoxifen-treated mice
abnormal reproductive system development ( J:148515 )
• prospective corporal bodies from tamoxifen-treated mice fail to differentiate or bilaterally segment in the mesenchyme unlike in wild-type mice
• however, development of internal reproductive organs are normally in tamoxifen-treated mice

renal/urinary system
abnormal foreskin morphology ( J:148515 )
• underdeveloped in tamoxifen-treated mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory